Inflammasome apoptosis. Caspase-1 then promotes the secretion of IL-1β and I...
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Inflammasome apoptosis. Caspase-1 then promotes the secretion of IL-1β and IL-18 and a rapid form of lytic programmed cell death termed pyroptosis. 1 day ago · The NLRP3 inflammasome is a multiprotein complex that consists of NLRP3, apoptosis-associated speck-like protein (ASC), and Caspase-1. This section summarizes the stepwisemechanismsunderlying its activation— from canonical ionic and particulate triggersto mitochondrialand metabolic integration,structurallicensing,and non Recent evidence highlights the importance of pyroptosis, a lytic and highly inflammatory form of programmed cell death, in the pathogenesis of lipopolysaccharide (LPS)-induced lung injury. Moreover, inhibition of NF-κB by PDTC aggravated the inhibitory effects of α-mangostin on NLRP3 inflammasome activation and apoptosis in LPS-induced NPCs. Jun 1, 2013 · Canonical inflammasomes, including NLRP3, NLRC4, and AIM2, recruit and activate caspase-1 in response to a range of microbial stimuli and endogenous danger signals. These findings suggested that α-mangostin exerted a protective effect on NLRP3 inflammasome-mediated apoptosis in LPS-induced NPCs through regulating NF-κB signaling. 3–5 In contrast to apoptosis, pyroptosis is typically mediated by inflammasome activation, such as the NLRP3 (NOD-like receptor familypyrin domain Jan 30, 2026 · Collectively, the integrated suppression of PKC/NF-κB/NLRP3–ncRNA neuroinflammatory signaling by tannins limits inflammasome activation, reduces neuronal apoptosis, and mitigates ischemia-induced neuronal loss. Jan 7, 2020 · Recent studies identified mediators of inflammasome-associated cell death and suggested that inflammasomes induce not only pyroptosis, but also apoptosis. reveal that inhibition of mitochondrial ATP production and of apoptosis are common effects of NLRP3 activators, suggesting that it evolved for their sensing. Jan 5, 2024 · Inflammasome formation typically occurs in response to infectious agents or cellular damage. 7 macrophages. Aug 26, 2011 · Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis spp. Nov 20, 2024 · Saller et al. It inhibited hepatocyte apoptosis by modulating Bcl-2/Bax expression and suppressed NLRP3 inflammasome activation. L. . Jan 7, 2020 · Active caspase-1 induces pyroptosis, a necrotic form of regulated cell death, which facilitates the release of intracellular proinflammatory molecules, including IL-1 family cytokines. 3–5In contrast to apoptosis, pyroptosis is typically mediated by inflammasome activation, such as the NLRP3 (NOD-like receptor familypyrin domain-containing Apr 30, 2024 · We also demonstrated the contribution of PE_PGRS38 in the pathogenesis of tuberculosis by investigating its role in intracellular survival, inflammation, the inflammasome, and apoptosis of the infected RAW264. Multiple inflammasomes that differ 5 days ago · The activation of the NLRP3 inflammasome, in turn, can induce granulosa cells necrosis, apoptosis, and follicular dysfunction, thereby contributing to the pathogenesis of PCOS [19]. The active inflammasome then triggers caspase-1 activation, followed by the secretion of In conclusion, significant progress was made in recent years in characterizing inflammasome-associated apoptosis, but more work is needed to examine when and how they contribute to inflammasome signaling in vivo. PKC–NF-κB–NLRP3 inflammasome axis and its non-coding RNA (ncRNA) regulatory network triggers robust innate immune activation and neuroinflammation, culminating in neuronal NLRP3 inflammasome activation is a multi-layered process that integrates diverseextracellularandintracellular signals into a unified inflammatory response. Recent studies identified mediators of inflammasome-associated cell death and suggested that inflammasomes induce not only pyroptosis, but also apoptosis. paracasei 36 restored intestinal microbiota balance, increasing beneficial genera (Ligilactobacillus, Akkermansia) and reducing harmful ones (Alistipes, Parasutterella). Additionally, previous research has suggested that PLAU (plasminogen activator, urokinase) can promote the activation of STAT3 [20, 21]. Oct 9, 2025 · Inflammasome sensor proteins are activated by microbial molecular patterns, endogenous self-derived damage signals, or exogenous environmental danger signals. Recent studies identified mediators of inflammasome-associated cell death and suggested that inflammasomes induce not only pyroptosis, but also apoptosis. Jul 28, 2021 · Recent studies have revealed that NLRP3 inflammasome activation contributes to not only pyroptosis but also other types of cell death, including apoptosis, necroptosis, and ferroptosis. Feb 22, 2026 · In addition, we analyzed NP formation using phosphorylated tau at threonine 217 (pTau217) and Aβ antibodies along with inflammasome sensors using NOD-like receptor protein (NLRP) antibodies, apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) and absent in melanoma-like receptor 2 (AIM2). is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts 4 days ago · Recent evidence highlights the importance of pyroptosis, a lytic and highly inflammatory form of programmed cell death, in the pathogenesis of lipopolysaccharide (LPS)-induced lung injury.
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